The key card is present but its support is thin.
Prioritize useful support such as Frog Butler or Mouser Foundry.
With Michelangelo present, sacrifice a spare artifact during your turn. His end-step counter improves future Tenderize damage.
Your deck already enables the plan but is losing the early turns.
Take a castable early creature or efficient answer before a second expensive payoff.
A Mutagen or Food still costs mana to activate. Include that cost when planning both the sacrifice and your main spell.
The support is missing
Favor independently useful creatures and interaction if the narrow support does not arrive.